July 24, 2008 Gene mutations linked to pain with statins Play video

(NECN/ABC) - New research shows that people who have certain tiny mutations in a single gene are much more likely to experience pain and muscle weakness while taking a statin drug to lower cholesterol. Researchers say a test for these mutations could identify those at risk and help them avoid the side effects.

Millions of Americans take statin drugs such as Lipitor or Zocor to help lower their cholesterol - but for some, the medications trigger muscle aches and pains.

However, a new genetic discovery may make it possible to test patients for their risk of side effects BEFORE they start taking a statin.

Doctors compared the genes of people who developed muscle pain and weakness while taking Zocor to the genes of patients who did NOT have side effects.

Results showed that tiny mutations in a gene that helps process statins in the body DRAMATICALLY increased the odds of muscle problems.

Patients with NO copies of the risky gene had less than a 1 percent chance for muscle-related side effects, while those with TWO copies had an 18 percent chance.

Researchers say the gene would be easy to test for, and those at high risk could skip statins or start with a LOW dose.

But some experts question whether an expensive genetic test is practical, or even necessary, because most side effects from statins are MILD and EASILY reversed.

ABC's Dr. Timothy Johnson reports.